Niacin or Fibrate

Types of Niacin and Fibrate

Niacin and fibrates are both medications used to treat high cholesterol. They work to decrease low-density-lipoprotein (LDL), or “bad” cholesterol and triglycerides, and increase high-density-lipoprotein (HDL), or “good” cholesterol. While both types of medications are effective for lowering cholesterol, they do so in different ways.

  1. Niacin: This is a B-vitamin that works by increasing the level of HDL in the blood. It also reduces the activity of enzymes that break down triglycerides.
  2. Fibrates: These are drugs that work to reduce the production of triglycerides and remove excess triglycerides from the blood.

Niacin and fibrates should be used in combination with lifestyle changes, like a healthy diet and exercise, to get the most benefit. Both can cause side effects, so it’s important to talk to your doctor before starting either medication.

Benefits of Niacin

Niacin, also known as vitamin B3, is an essential nutrient that plays an important role in many body functions. It helps convert food into energy and has been known to reduce cholesterol levels, decrease inflammation, and lower the risk of heart disease. Additionally, studies have also shown that niacin may help to improve brain function, as well as reduce symptoms of anxiety and depression. In addition, it can help to improve skin texture, reduce wrinkles, and even help to fight off certain types of cancer. All of these benefits make niacin a great choice for those looking to improve their overall health and wellbeing.

Benefits of Fibrate

Fibrates are medicines used to lower cholesterol and triglyceride levels in the body. They work by increasing the production of LDL (low-density lipoprotein) cholesterol and reducing the production of VLDL (very-low-density lipoprotein) cholesterol. Fibrates have also been proven to reduce the risk of heart attack and stroke in patients with high levels of cholesterol. Additionally, they can help to reduce inflammation in the blood vessels and reduce the risk of developing diabetes. Fibrates can also be used to treat some types of pancreatic dysfunction. They are usually taken orally as a tablet or capsule, and can be used in combination with other cholesterol-lowering medications, such as Niacin. When taken as prescribed, Fibrates are usually safe and well tolerated, with few side effects.

Side Effects of Niacin

Niacin is a prescription medication used to treat high cholesterol and triglyceride levels. It is also known as Vitamin B3 and is found in a variety of food sources. While taking niacin can be beneficial to one’s health, it should be noted that it also has side effects. Common side effects of taking niacin include itching, flushing, headaches, and gastrointestinal issues. In rare cases, more severe side effects like liver damage and elevated levels of glucose, triglycerides and uric acid have been reported. As such, it is important to seek doctor’s advice before starting niacin therapy and consult with a medical professional or pharmacist regarding potential side effects. Additionally, those who are by gender pregnant or breastfeeding should avoid taking niacin altogether.

Side Effects of Fibrate

Fibrates are a class of drugs used to lower cholesterol levels and triglyceride levels. They work by increasing the activity of enzymes that help break down triglycerides in the blood. While fibrates are generally considered safe, there are some potential side effects associated with them. Some of the most common side effects include diarrhea, constipation, indigestion, headache, dizziness, rash, and muscle pain. Rarely, fibrates can cause nausea, abdominal pain, and liver problems. If you experience any side effects from taking fibrates, it is important to contact your doctor immediately. Taking fibrates can also increase your risk for developing gallstones and pancreatitis. These conditions can be serious and should be monitored carefully.

Niacin vs Fibrate

Niacin (vitamin B3) and fibrates are both popular medications used to lower cholesterol levels and triglyceride concentrations in people with high levels of fats (lipids) in their blood. Niacin is an alternative to statin drugs, while fibrates are used to supplement statin therapy when the patient needs a higher level of lipid reduction than statins alone can provide. Niacin works to reduce low-density lipoprotein (LDL) cholesterol, the so-called “bad” cholesterol, while fibrates reduce triglycerides and increase high-density lipoprotein (HDL) cholesterol, the “good” cholesterol. Both medications can lead to improved blood lipid levels, though they also come with potential unpleasant side effects that may limit their effectiveness. It is important to discuss with a healthcare professional which treatment option is best in order to get the most benefit while minimizing the risk of unwanted side effects.


In conclusion, niacin and fibrates are both effective medicines in treating various cardiovascular diseases; however, both can carry serious side effects when combined with other drugs or when taken in excess. Niacin should be taken in low doses, as it can cause discomfort such as flushing and itching. Fibrates should be taken with caution, as they can interfere with some medications and increase the risk of kidney damage. Talk to your doctor if you are considering taking either niacin or a fibrate to ensure the benefits outweigh the risk.

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