The Effectiveness of Nicotinic Acid Niacin: Its Action.


Niacin, or nicotinic acid, is a naturally occurring form of vitamin B3, first discovered in the early 1800s. For most of the twentieth century, it was an effective, inexpensive treatment for pellagra and other ailments caused by vitamin deficiencies, such as schizophrenia and anxiety. Over the years, researchers have come to understand just how important niacin is to human health. Niacin is responsible for the synthesis of certain important molecules and enzymes, helps to break down carbohydrates, lipids and proteins into energy, and plays a role in proper circulation. It is also used to treat high cholesterol, diabetes and other diseases. Niacin supplementation has been linked to reducing the risk of stroke and heart attack, as well as having beneficial effects on mental acuity, mood and sleep.

Mechanism of Action

Nicotinic acid, more commonly known as niacin, is one of the most effective treatments for high cholesterol and high triglyceride levels. It works by increasing the levels of lipoprotein (HDL) in the blood, which helps to reduce the risk of cardiovascular disease and improve overall health. Niacin also helps to reduce LDL, or bad cholesterol, levels by blocking the liver from producing too much LDL. In addition, niacin has shown to have anti-inflammatory properties, which can help reduce the risk for certain types of cancer. The exact mechanism of action of niacin is unknown, but it is believed to reduce the number of cellular receptors that are responsible for cholesterol absorption. This helps to reduce the amount of cholesterol that is absorbed from the intestine and reabsorbed from the liver. Ultimately, niacin works by increasing the good cholesterol levels in the body and reducing the bad cholesterol levels, thus improving overall health.

Clinical Application

Nicotinic acid (niacin) is widely used in clinical applications. It is primarily used to improve blood lipid profiles, i.e. reduce LDL cholesterol and triglycerides, and increase HDL cholesterol. Nicotinic acid is also used in the treatment of pellagra, diabetes, and hyperuricemia. It has been found to be effective in preventing and decreasing arterial plaque buildup and blood clotting, and increasing red blood cells production. Nicotinic acid is a safe, effective anti-hyperlipidemic agent, and it has a beneficial effect on diabetes, due to its anti-inflammatory properties. Its anti-inflammatory action reduces the risk of diabetic complications, such as heart and kidney disease, and retinopathy. Additionally, nicotinic acid is beneficial in improving mental health, as it increases dopamine production, which might be useful in the treatment of some mental disorders. This highlights the effectiveness of niacin as a potential treatment for an array of medical conditions.

Side Effects

Nicotinic acid, or niacin, is a very effective medicine for treating various medical conditions. However, it is important to note that it also has some side effects. Most common side effects of niacin are mild and include flushing, stomach upset and headache. More serious side effects may include liver damage, increased risk of bleeding, and gout. It is often recommended that people taking niacin on a regular basis should monitor their liver function regularly. For some people, certain lifestyle changes, such as avoiding alcohol, can reduce the risk of side effects. Furthermore, different doses and forms of niacin may affect the body differently. Therefore, it is best to consult a healthcare professional before taking niacin to determine the best dose and form for you.


In conclusion, it is clear that nicotinic acid niacin has been shown to be an effective medicine for treating a variety of medical conditions. It has been seen to have a positive effect on cholesterol levels, reducing the risk of cardiovascular disease, and can help reduce inflammation. By understanding the action of niacin, it is possible to use it safely and effectively to treat medical conditions. Taking into consideration the potential side effects, it is important to consult with a doctor before taking niacin to ensure that it is the best choice for an individual’s medical condition.

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